Timing is important
when diagnosing
and treating CPP1,2

Early puberty, or central precocious puberty (CPP), can have lasting
complications beyond childhood. Timely treatment may help
prevent those complications.1-4

CPP can affect your child both physically and emotionally, and those effects can carry into adulthood.5 If your child is
diagnosed with CPP, the sooner he or she starts treatment, the sooner the progression of puberty may be stopped.

Your child’s pediatrician is your
first step in getting a diagnosis.5-8

He or she knows your child’s medical history. If you notice any signs or symptoms of puberty occurring too soon, speak with your child’s doctor. Let him or her know your concerns. The doctor will review your child’s and family’s medical history and do a physical exam. In the meantime, prepare for your doctor's visit by using our Interactive Growth Tool to compare the signs of puberty you see in your child to the stages of puberty in normal development.

Taking the next steps

Hear Karen Klein, MD, Pediatric Endocrinologist,
discuss next steps in treatment for CPP.

Seeing a pediatric endocrinologist8-10

If your pediatrician thinks your child may have CPP, he or she may refer you to a pediatric endocrinologist to make an official diagnosis. Pediatric endocrinologists are specialists who focus on the treatment of hormone-related conditions in children.

The pediatric endocrinologist may perform some or all of the tests below. Once all the tests are complete, he or she will review the results and make a proper diagnosis.

Need a Pediatric Endocrinologist?

Need a Pediatric Endocrinologist?

While AbbVie does not recommend any specific healthcare providers, we can help you find a pediatric endocrinologist in your area.

Tests that can help diagnose CPP6,9,11-13

  • Bone age test
  • An X-ray of the left hand can help determine your child’s bone age. It is then compared to standard growth charts to establish whether the bones are growing too quickly.
  • Blood test
  • This test measures the level of hormones in your child’s bloodstream.
  • GnRH stimulation test
  • This test helps distinguish CPP from other possible causes of early puberty.
  • Pelvic and adrenal ultrasound
  • This checks the development of your child’s ovaries or testicles, and adrenal glands.
  • MRI or CT scan
  • These tests show if any brain abnormalities are causing the early start of puberty.

If your child is diagnosed with CPP, remember that it can be treated.3,5 Before choosing a treatment, discuss with the doctor how it works and how it can affect your child.

Customize your own
Doctor Discussion Guide

It’s important to ask the right questions and get as much information as possible during your doctor’s visit. To help with this, we’ve created a Doctor Discussion Guide for you to print and take with you when you see your child’s pediatrician and/or pediatric endocrinologist.


Next Steps:


The Future:

How is CPP treated?6,10

The most common treatment for CPP, or central precocious puberty, is called a gonadotropin-releasing hormone (GnRH) agonist. GnRH agonists work by helping the pituitary gland ignore signals from the brain so it stops sending hormones that stimulate the ovaries and testes. That, in turn, stops the production of sex hormones.

Once your pediatric endocrinologist decides that your child has reached a more appropriate age, he or she will stop GnRH agonist therapy, and your child will go through “normal” puberty just like his or her peers. The amount of time a child is on treatment will depend on his or her unique growth and development. The pediatric endocrinologist may also tell you that not all children require treatment.

Find out more about a treatment option

CPP treatment options

Hear Peter A. Lee, MD, Pediatric Endocrinologist,
discuss treatment for CPP.

References: 1. Guaraldi F, Beccuti G, Gori D, Ghizzoni L. MANAGEMENT OF ENDOCRINE DISEASE: Long-term outcomes of the treatment of central precocious puberty. Eur J Endocrinol. 2016;174(3):R79-R87. 2. Fuqua JS. Treatment and outcomes of precocious puberty: an update. J Clin Endocrinol Metab. 2013;98(6):2198-2207. 3. Carel JC, Lahlou N, Roger M, Chaussain JL. Precocious puberty and statural growth. Hum Reprod Update. 2004;10(2):135-147. 4. Partsch CJ, Sippell WG. Pathogenesis and epidemiology of precocious puberty. Effects of exogenous oestrogens. Hum Reprod Update. 2001;7(3):292-302. 5. Mayo Clinic Staff. Precocious puberty: symptoms and causes. Mayo Clinic website. http://www.mayoclinic.org/diseases-conditions/precocious-puberty/symptoms-causes/syc-20351811. Published November 17, 2017. Accessed March 21, 2018. 6. Carel JC, Léger J. Clinical practice. Precocious puberty. N Engl J Med. 2008;358(22):2366-2377. 7. Central Precocious Puberty (CPP). WebMD website. https://www.webmd.com/children/central-precocious-puberty#2-6. Accessed March 21, 2018. 8. Muir A. Precocious puberty. Pediatr Rev. 2006;27(10):373-381. 9. Mayo Clinic Staff. Precocious puberty: diagnosis & treatment. Mayo Clinic website. https://www.mayoclinic.org/diseases-conditions/precocious-puberty/diagnosis-treatment/drc-20351817. Published November 17, 2017. Accessed March 21, 2018. 10. Kletter GB, Klein KO, Wong YY. A pediatrician's guide to central precocious puberty. Clin Pediatr (Phila). 2015;54(5):414-424. 11. Blondell RD, Foster MB, Dave KC. Disorders of puberty. Am Fam Physician. 1999;60(1):209-218, 223-224. 12. Mazgaj M. Sonography of abdominal organs in precocious puberty in girls. J Ultrason. 2013;13(55):418-424. 13. Rieth KG, Comite F, Dwyer AJ, et al. CT of cerebral abnormalities in precocious puberty. AJR Am J Roentgenol. 1987;148(6):1231-1238.